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Ivermectin and Multiple Sclerosis

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Ivermectin and Multiple Sclerosis – Anti-inflammatory action, neuroprotection and re-myelination!

New 2023 study by Iranian researchers, shows Ivermectin treats Multiple Sclerosis in mice:

2023 Noori et alSynthesis and evaluation of the effects of solid lipid nanoparticles of ivermectin and ivermectin on cuprizone-induced demyelination via targeting the TRPA1/NF-kB/GFAP signaling pathway

Ivermectin (IVM) and nano-IVM administration improved behavioral alterations and motor balance in all performed tests demonstrating a reduction in the adverse effects of Cuprizone (CPZ) on myelin”

“To study MS in animal models, the most common method is to trigger the pathology with cuprizone (CPZ). CPZ is a copper chelator whose use induces programmed death in oligodendrocyte cells, chronic inflammation, increased astrocyte and microglial cell activity, and ultimately, myelin destruction

Histological analysis (H&E and LFB staining) evidenced that IVM and nano-IVM normalized the morphological alteration induced by CPZ

Specifically, the nano-formulation of IVM improved its neuroprotective effects via reducing demyelination or maybe inducing myelin regeneration.

This adds to the 2018 study by Zabala et al:

“Our results provide evidence that P2X4Rs modulate microglia/macrophage inflammatory responses and identify IVM as a potential candidate among currently used drugs to promote the repair of myelin damage.

“Manipulating innate immune system to promote repair might be a promising therapeutic strategy for treating MS. The results of our study identify P2X4R as a key modulator of microglia/macrophage polarization and support the use of IVM to potentiate a microglia/macrophage switch that favors remyelination in MS.

“The fact that IVM is already used as an anti‐parasitic agent in humans will facilitate challenging this drug in clinical trials in that demyelinating disease.”